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KMID : 1123920080220030600
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Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 3 p.600 ~ p.606
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Anti-allergic Inflammatory Effects of Hwangyounhaedog-tang on PMA Plus A23187-stimulated RBL-2H3 Cells
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Baek Sang-In
Bae Jong-Hoon
Kim Jin-Young
Sim Sung-Heum
Kang Kyung-Hwa
Lee Seung-Yeon
Kam Cheol-Woo
Park Dong-Il
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Abstract
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The purpose of this study was to investigate Anti-allergic Inflammatory Effects of Hwangyounhaedog-tang on PMA plus A23187-stimulated RBL-2H3 cells. We examined MTT assay, -hexosaminidase activity, IL-4 and TNF- from RBL-2H3 after pre-treatment with HHT. In addition, we investigated expression of COX-1 and COX-2 mRNA using RT-PCR study. The results are as follows: All the concentrations of HHT from 1 to 4 mg/ml didn’t have an effect on cell viability. In RBL-2H3 cells, -hexosaminidase release, IL-4 and TNF- were significantly reduced by treated all concentrations of HHT. COX-2 on mRNA expression was reduced at treatment 2mg of HHT prior to stimulating by A23187. These results indicate that HHT has inhibition effects on allergy in this study.
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KEYWORD
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Hwangyounhaedog-tang, Anti-allergic Inflammatory Effects
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